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Musculoskeletal Corticosteroids decrease bone formation and increase bone resorption both through their effect on calcium regulation (i.e., decreasing absorption and increasing excretion) and inhibition of osteoblast function. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality day changes, and severe depression, to frank psychotic manifestations. Drug Discontinuation: -Abrupt discontinuation after hydrochlorothiazide medication high-dose or long-term therapy should be avoided. Although many of the undesirable features purchase of corticosteroid therapy can be minimized by alternate day therapy, as in any therapeutic situation, the physician must carefully weigh the benefit-risk ratio for each patient in whom corticoid therapy is being considered. 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